The assessment of cysteinyl leukotriene receptor antagonist role in inhibition of atherosclerosis, proliferation and its influence on endothelial function in patients undergoing endovascular treatment due to peripheral arterial disease

Description of the study: Atherosclerosis is a disease of modern civilization with pathophysiology based on a chronic inflammatory response in the vessel walls caused by an increase in pro-inflammatory substances. It brings great challenges to the fields of diagnostics and pharmacology. It occurs in more than 60% of the population of people over the age of 70. There are many substances responsible for the process of this condition including a group of arachidonic acid derivatives - leukotrienes (LT), in particular leukotriene E4 (LTE4). The main goal of this study is to investigate the influence of the use of cysteinyl leukotrienes receptor antagonists on lower limbs arteries reocclusion rate in patients with peripheral artery occlusive disease (PAOD) after endovascular treatment.

Jagiellonian University Medical College

EudraCT number:

Project Manager/Main Investigator:
dr hab. Paweł Maga

Duration of the study:
2020 - Ongoing